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hematology differential oncology algorithm management chronic cll common community cvid gap globulin hemophagocytic hlh hypogammaglobulinemia immunodeficiency immunology leukemia lymphocytic lymphohistiocytosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... cells can infiltrate ... Diagnosis: • ... #workup #oncology ... #hematology
Community Acquired Pneumonia - Presenting Features • History in favor of CAP: Dyspnea, Cough, particularly if
Community Acquired ... criteria: Septic shock ... platelet <100k cells ... #Pneumonia #diagnosis ... #signs #symptoms
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Too many cells in ... Better call hematology ... - Acquired: polycythemia ... you’ll do a good workup ... #Algorithm #workup
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Entities That Can ... Lymphoma (HCV) • CLL ... angioedema • vWD • acquired ... Paraproteinemias #Hematology ... #Differential #Diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... : HLH signs and ... symptoms can mimic ... Low or absent NK cell ... management #treatment #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to impaired B-cell ... -> 40 years • Can ... severe community-acquired ... : • Nephrotic syndrome ... (Epstein-Barr syndrome
Differential diagnosis of the reversed halo sign (RHS). AIA, angioinvasive aspergillosis; AIS, adenocarcinoma in situ; COP,
Differential diagnosis ... reversed halo sign ... opacities, as well ... patients with acquired ... immunedeficiency syndrome
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
Diagnosis? ... EMD myeloma Diagnostic ... chemotherapy as required ... Plasmacytoma #Oncology #Diagnosis ... #Workup #Hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... myeloma • Plasma cell ... changes (POEMS syndrome ... Thalassemia, Sickle cell ... #differential #diagnosis
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