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management diagnosis cdiff clostridioides clostridium cytomegalovirus difficile gastroenterology hemophagocytic hivaids hlh infection infectiousdiseases lymphohistiocytosis opportunistic pharmacology prevention rheumatology summary
C.diff - Clostridioides Difficile Infection (CDI) - Diagnosis and Management - GrepMed Handbook Clinical Presentation + Progression:
Toxic Megacolon, Shock ... Epidemiology: • #1 ... can be community-acquired ... 10 mg/kg IV x 1 ... IDSA 2021 CDI
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... Purtilo (XLP) Acquired ... +: Virus (EBV, CMV ... Histoplasmosis, candidiasis ... immune deficiency, Drugs
IDSA Recommendations for Treating Cytomegalovirus Infections in HIV-AIDS Preventing CMV Disease: • CMV end-organ disease is best
IDSA Recommendations ... ART to maintain CD4 ... ) for 1–4 doses ... intraocular levels of drug ... #IDSA #Prevention
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