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C.diff - Clostridioides Difficile Infection (CDI) - Diagnosis and Management - GrepMed Handbook

Clinical Presentation + Progression:
Infection (CDI) ... Toxic Megacolon, Shock ... can be community-acquired ... Ileus, Megacolon, Shock ... #diagnosis #management
Causes of Antibiotic Failure - Differential Diagnosis Framework
Diagnosis:
 • Non-Infectious: Malignant, Autoimmune, Drug-related (NMS, serotonin syndrome,
Bug: Atypical bacteria ... Immunocompromise Treatment ... • Secondary to Treatment ... diff) • Hospital-Acquired ... Difficile, COVID
IDSA Recommendations for Preventing and Treating Bacterial Enteric Infections in HIV-AIDS
Preventing Bacterial Enteric Illness:
 • Antimicrobial
IDSA Recommendations ... Enteric Infections ... Treating Clostridium difficile ... #IDSA #Prevention ... #Treatment #management
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Auto-amplification loop Diagnosis ... Purtilo (XLP) Acquired ... CMV, HHV8,...), Bacteria ... Unknown cause Treatment ... #management #treatment
Orthopedic Emergencies
Compartment Syndrome
 • An increase in compartment pressure to the point where tissue perfusion is
progressive inflammatory infection ... • Diagnosis: ... including DM • Treatment ... #Emergencies #diagnosis ... #management #treatment
IDSA - Approach to Treating a Patient With Diabetic Foot Osteomyelitis
When to consider a trial of
IDSA - Approach ... of nonsurgical treatment ... 48–72 h if on treatment ... #nonoperative #management ... #IDSA
Fusarium Infections
Acquired through:
1. Inhalation of airborne conidia > germinates > blood > disseminated
2. Trauma (implantation with
Acquired through ... with botanical material ... disease: • Optimal treatment ... infectiousdiseases #diagnosis ... #management