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diagnosis differential liver injury lfts alcoholic chemistry diffuse druginduced elevated emesis function hematology interpretation lad lymphadenopathy management nausea oncology patterns
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Cirrhosis • Chronic ... Hepatopathy • Acute ... (>1000): • DILI ... liver injury) • Ischemic ... #transaminitis
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
> 50x normal - Ischemic ... 20x normal - Acute ... 5-10x normal - Chronic ... Liver #Injury #hepatology ... #LFTs #transaminitis
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Transaminases / Transaminitis ... • Iatrogenic: DILI ... See Updated Schema ... Differential #Diagnosis #causes ... #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... for alternative causes ... disease, Hepatic ischaemia ... dechallenge • Acute ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... Vascular Causes ... • Iatrogenic: DILI ... > 2 • NASH, Chronic ... #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
viral hepatitis ... > 2 • NASH, Chronic ... injury: > 3 • Chronic ... #differential #Hepatology ... #transaminitis
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... Tuberculosis • Hepatitis ... Fatigue • Acute ... Age > 50 • Chronic ... #Causes #Hematology
Nausea and Vomiting - Differential Diagnosis Algorithm Upper Gastrointestinal - Acute • Infectious Gastroenteritis • Gastric/Duodenal Obstruction
Differential Diagnosis Algorithm ... Gastrointestinal - Chronic ... • Mesenteric Ischemia ... Hepatitis • Acute ... #Causes
Alcoholic Hepatitis - Management Algorithm Assess Eligibility for Treatment: - Maddrey Discriminant Function ≥ (or possibly MELD
Alcoholic Hepatitis ... - Management Algorithm ... exclude other causes ... HCV, DILI, HCC, ... #hepatology
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