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Algorithm for the Evaluation and Management of Sickle Cell Crises
Clinical Manifestations and Management

#Diagnosis #Management #Hematology #SickleCell
Algorithm for the ... Evaluation and Management ... of Sickle Cell Crises ... #Hematology #SickleCell ... Manifestations #Workup #Algorithm
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
Causes of Bone/Joint ... • Mechanism: ischemic ... #Joint #Pain #SickleCell ... differential #diagnosis #causes ... #hematology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
high WBC count cause ... visual changes, stroke ... AKI, acute limb ischemia ... TLS #diagnosis #management ... #hematology
Treatment of giant cell arteritis (GCA)

1st Line Strategy - GC 0.7 mg/kg/day, except for:
 • Aortitis
mg/kg/day • Ischemic ... scalp necrosis, stroke ... MTX or TCZ in case ... GCA #Treatment #Management ... #Indications #rheumatology
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
Related conditions: Stroke ... limb and bowel ischemia ... cryoglobulins • Negative causes ... Cryofibrinogenemia #diagnosis #rheumatology ... #hematology
Perhaps quite too often, the knee-jerk reaction to an elevated Troponin is to call our friends
cannot, coronary ischemia ... treat the primary cause ... may not be the case ... #diagnosis #management ... l#foamed #algorithm
Perhaps quite too often, the knee-jerk reaction to an elevated Troponin is to call our friends
cannot, coronary ischemia ... treat the primary cause ... may not be the case ... #diagnosis #algorithm ... #management #clinical
Preoperative Risk Evaluation

Major Pre-Op Questions:
1. Does the patient have any modifiable risk factors that could be
history of: a) Ischemic ... event, follow ACC algorithm ... one post op Cardiology ... • <6mo since stroke ... medical and surgical management
Essential Thrombocythemia (ET)
ET is a chronic myeloproliferative neoplasm. Most cases are related to mutations that affect
Most cases are related ... • Treatment algorithms ... Thrombocythemia #ET #hematology ... #diagnosis #management ... #hematology