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hemolytic oncology classification common cvid extravascular hodgkins hypogammaglobulinemia immunodeficiency intravascular lymphoma macrocytic macrocytosis mds myelodysplasia nonpalpable palpable purpura rheumatology syndromes
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... microangiopathy: Thrombotic thrombocytopenic ... lymphoproliferative disorders ... #differential # ... diagnosis #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Diagnosis Algorithm ... • Small Bowel Disorder ... Diagnosis #Algorithm ... #Causes #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Diagnosis Algorithm ... #Anemia #Differential ... #Diagnosis #Algorithm ... #workup #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
DIC/TTP/HUS - Hemolytic ... anemia - Splenomegaly ... fever • Drug reactions ... #Diagnosis #hematology ... #nonpalpable #dermatology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
for Thrombotic Thrombocytopenic ... Fibrin degradation products ... anemia Indirect ... WBC count and differential ... #Workup #Hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... formed or don’t work ... blood count with differential ... #Syndromes #diagnosis ... #hematology #oncology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Immunodeficiency disorder ... and autoimmune hemolytic ... anemia) • Systemic ... DDX - Other causes ... #hematology #diagnosis
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... genes and gene products ... Hodgkin Lymphoma Workup ... classification #hematology ... #oncology #management
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