8 results
Classification of Jaundice
Unconjugated hyperbilirubinemia (predominantly indirect bilirubin)
 • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
Classification of Jaundice ... drug reactions) Conjugated ... postoperative jaundice ... neoplasms #Jaundice ... differential #causes
Jaundice - Pathophysiology and Causes

- Amy Chung, MD, MSc @AmyChung 

#Jaundice #Pathophysiology #Differential #Unconjugated #Causes #Diagnosis
Jaundice - Pathophysiology ... Amy Chung, MD, MSc ... #Pathophysiology ... #Differential # ... Unconjugated #Causes
Inherited Non-hemolytic Disorders of Hyperbilirubinemia 

== Disorders of Conjugation ==
Gilbert Syndrome:
 • 5-10% of the population
hemolysis or liver injury ... breastfeeding jaundice ... and breastmilk jaundice ... manifest only as jaundice ... • Increase in conjugated
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
- Differential ... • Bilirubin - ... week • Direct bilirubin ... : ~ 1 Unconjugated ... #hepatitis #differential
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Bilirubin - ... week • Direct bilirubin ... Elevation: • Bilirubin ... blood cells Unconjugated ... chemistry #diagnosis #differential
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
65 years PBC Pathophysiology ... hyperpigmentation • Jaundice ... slightly elevated • Bilirubin ... bile ducts Differential
Meralgia paresthetica: Pathogenesis and Clinical Findings
Compression/injury of Lateral Femoral Cutaneous Nerve (LFCN) -> Meralgia paresthetica
 •
Findings Compression/injury ... MeralgiaParesthetica #MSK ... #pathophysiology ... #differential #
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
10-33% develop MS ... monophasic Pathophysiology ... Presentation: Injury ... Predictive of MS ... management #neurology #differential