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diagnosis hematology differential causes oncology thrombocytosis cll lymphocytic algorithm alkaline alp bandemia cbc disease hemeonc hyophosphatasia low management mds myelodysplasia
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
Reactive: • Anemia ... Myelofibrosis • Chronic ... Myeloid Leukemia ... causes #Platelets #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Polycythemia Vera • Chronic ... Myelogenous Leukemia ... : • Acute or Chronic ... Iron deficiency anemia ... Algorithm #Causes #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
malignancies • Anemia ... hemorrhage) • Chronic ... Myelofibrosis (MF) • Chronic ... myeloid leukemia ... Diagnosis #Causes #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... with a relatively chronic ... involvement CML (Chronic ... - infiltrates (anemia ... #Hematology #Oncology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... 5) Symptoms of anemia ... marrow failure with anemia ... uw_IMresidency #CLL #Chronic ... #oncology #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Leukemia - Summary ... • Neutropenia, anemia ... #CLL #Chronic ... workup #oncology #hematology
Anemia of Chronic Disease - Pathophysiology One theory to explain why "anemia of chronic disease" exists: The inflammatory
Anemia of Chronic ... Disease - Pathophysiology ... #anemia #chronic ... #disease #hematology ... #pathophysiology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Bandemia Overview ... Tissue damage • Leukemia ... Degree of bandemia ... neutrophil #WBC #CBC #hematology ... #pathophysiology
Widened Pulse Pressure - Differential Diagnosis and Pathophysiology Pulse pressure is the difference between the systolic blood
Diagnosis and Pathophysiology ... iron deficiency anemia ... disorders - Chronic ... Differential #Diagnosis #Pathophysiology ... #causes #cardiology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
• Aplastic Anemia ... Marrow Failure • Chronic ... Myelogenous Leukemia ... • Hairy Cell Leukemia ... Syndromes #diagnosis #hematology
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