7 results
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... thrombin #clot #PT ... #pathophysiology ... anticoagulant #Warfarin #Dabigatran ... Rivaroxaban #Edoxaban #heparin
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
• Prolonged PT ... protein C and S Pathophysiology ... Fibrinogen: ↓ • PT ... 100mg/dL) - Heparin ... treatment #management #hematology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
unfractionated heparin ... cause e.g. heparin ... intravascular coagulation ... #differential #hematology ... #coagulation
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
for a Prolonged PT ... Pre-analytical cause (e.g. heparin ... thrombin inhibitors, heparin ... #differential #hematology ... #coagulation
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
inhibitor of a coagulation ... Acquired: • Heparin ... , dabigatran, argatroban ... intravascular coagulation ... Differential #Diagnosis #Hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
cardiac valves (septic ... Hyperhomocysteinemia - Heparin-induced ... intravascular coagulation ... Venous #Arterial #pathophysiology ... #hematology #differential
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
• Albumin • Coagulation ... factors: PT/INR ... replaced by non-hepatic ... #differential #Hepatology