11 results
Algorithm for Investigation of Abnormal Coagulation Tests
- Prolonged PT
- Prolonged aPTT and Prolonged PT
- Prolonged aPTT

Dr.
Investigation of Abnormal Coagulation ... PT - Prolonged ... PT - Prolonged ... #Algorithm #Coagulation ... APTT #Laboratory #Hematology
Causes of Prolonged PT (INR), Prolonged PTT
 • Prolonged PT (INR), Prolonged PTT
 • Prolonged PT
PT (INR), Prolonged ... PT (INR), Prolonged ... PT (INR), Normal ... Algorithm #Causes #Hematology ... #coagulation #disorders
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
unfractionated heparin ... cause e.g. heparin ... intravascular coagulation ... #differential #hematology ... #coagulation
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Thrombocytopenia • Prolonged ... PT/PTT • Low ... protein C and S Pathophysiology ... Fibrinogen: ↓ • PT ... treatment #management #hematology
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
PT and aPTT If ... Pre-analytical cause (e.g. heparin ... thrombin inhibitors, heparin ... #differential #hematology ... #coagulation
How to Evaluate an Abnormal APTT
Step 1: Is the PT or APTT Artifactually Prolonged?
Step 2: Is
Step 1: Is the PT ... Artifactually Prolonged ... K Antagonists, Heparin ... Prolonging the PT ... #diagnosis #hematology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... #Coagulation #Cascade ... thrombin #clot #PT ... #pathophysiology ... Rivaroxaban #Edoxaban #heparin
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
inhibitor of a coagulation ... Acquired: • Heparin ... prolonged after ... intravascular coagulation ... Differential #Diagnosis #Hematology
Commonly Observed Laboratory Findings in Hepatic / Liver Failure
 - Elevated conjugated and unconjugated bilirubin -
Laboratory Findings in Hepatic ... glycogen stores - Prolonged ... PT - Decreased ... #LiverFailure #Hepatic ... #Hepatology #Laboratory
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
cardiac valves (septic ... Hyperhomocysteinemia - Heparin-induced ... intravascular coagulation ... Venous #Arterial #pathophysiology ... #hematology #differential