14 results
Localization of Renal Tubular Defects
Fanconi Syndrome: Proximal tubule
Bartter Syndrome: Thick ascending loop of Henle
Gitelman Syndrome: Distal
Localization of Renal ... loop of Henle Gitelman ... Fanconi #Bartter #Gitelman ... Nephron #Defects #Pathophysiology ... #Nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
Primary Metabolic Alkalosis ... , Gitelman Syndrome ... hyperaldosteronism • High PRA: Renal ... Primary #Metabolic #Alkalosis ... Diagnosis #Algorithm #nephrology
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Gitelman Syndrome ... Hypokalemia Metabolic alkalosis ... #Syndrome #Pathophysiology ... #nephrology #diagnosis
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Primary Metabolic Alkalosis ... , Gitelman Syndrome ... hyperaldosteronism • High PRA: Renal ... aldosteronism #Metabolic #Alkalosis ... Diagnosis #Algorithm #Nephrology
Hypophosphatemia - Differential Diagnosis Algorithm
 • Decreased intake/absorption: Starvation, Alcoholism, Malabsorption, Phosphate binder use
 • Redistribution/
depletion: Respiratory alkalosis ... ), Hungry bone syndrome ... • Renal losses ... Algorithm #causes #nephrology ... #phosphate
Acid Base Disorders - Blood Gas Interpretation

Steps for Blood Gas Interpretation: 
1. Acidemia or Alkalemia? 
2.
ABG And BMP Normal ... D-lactate (short bowel syndrome ... salicylates) R Renal ... - Diarrhea - Renal ... Diagnosis #Summary #Nephrology
Workup for Hypophosphatemia - Differential Diagnosis Framework
Rule out spurious hypophosphatemia: paraproteinemia, acute leukemia
Measure Urine Fractional Excretion
Fractional Excretion of Phosphate ... Glucose, Acute resp. alkalosis ... FEPO4 ≥ 5% - Renal ... Framework #Workup #phosphate ... #nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... • Hypokalemia (renal ... , Renal tubular ... #nephrology #management ... #pathophysiology
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
Causes of Metabolic Alkalosis ... diuretics after renal ... generally indicates a renal ... furosemide-like lesion) • Gitelman ... Diagnosis #Causes #nephrology
Causes of Metabolic Alkalosis - Differential Diagnosis Algorithm
GI Losses - Gastric
 • Vomiting
 • NG suction
GI
Causes of Metabolic Alkalosis ... Chloridorrhea Renal ... Hypomagnesemia • Barrter's/Gitelman's ... Licorice • Liddle's Syndrome ... MetabolicAlkalosis #NonGap #Nephrology