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diagnosis hematology management oncology symptoms differential algorithm sle syndrome aplastic classification lymphocytic mds myelodysplastic thrombocytosis vasculitis arteritis avascularnecrosis basophilia basophils
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... (Chronic Myeloid ... -> AML: Blast crises ... - infiltrates (anemia ... #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Physical Exam/Signs ... • Neutropenia, anemia ... microglobulin Treatment ... leukemia #CLL
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... • Systemic Lupus ... Age > 50 • Chronic ... Reed-Sternberg Cells ... #Hematology #Oncology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... Leukemia (CLL) ... lymphocytes, smudge cells ... 5) Symptoms of anemia ... uw_IMresidency #CLL
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Illness Script Signs ... Treatment: • Consider ... stem cell transplant ... to MDS or acute leukemia ... #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... Myelogenous Leukemia ... effect following treatment ... Iron deficiency anemia ... #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... malignancies • Anemia ... myeloid leukemia ... (CML) - Dr. ... #hematology #secondary
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
= funny-shaped cells ... old, ~10,000 new cases ... cytopenias (usually anemia ... transformation to acute leukemia ... Allogeneic stem cell
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
similarly to mast cells ... Disorders: • Chronic ... Chickenpox Other Causes ... Differential #Diagnosis #causes ... #hematology #basophils
Oxyhemoglobin Dissociation Curve Left Shift - decreased unloading of O2 at tissue level (i.e. increased
stored red blood cells ... pregnancy • chronic ... anemia #Oxyhemoglobin ... Dissociation #Curve #Pathophysiology ... #Differential #Causes
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