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diagnosis management hematology oncology symptoms syndrome aplastic chronic classification differential lymphocytic mds myelodysplastic workup agammaglobulinemia algorithm arteritis avascularnecrosis cell centralretinalartery
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
APML, CLL Acute ... -> AML: Blast crises ... - infiltrates (anemia ... Phosphorus CLL ... #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... • Neutropenia, anemia ... microglobulin Treatment ... leukemia #CLL ... workup #oncology #hematology
Features of a Sickle Cell Crisis Sickle-cell disease - an autosomal recessive blood disorder. Characterized by red
Crisis Sickle-cell ... Crises can be precipitated ... The underlying pathophysiology ... of the baseline anaemia ... #Features #Signs
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
= funny-shaped cells ... old, ~10,000 new cases ... cytopenias (usually anemia ... transformation to acute leukemia ... Allogeneic stem cell
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Illness Script Signs ... Treatment: • Consider ... stem cell transplant ... to MDS or acute leukemia ... #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
(CLL) - Summary ... lymphocytes, smudge cells ... 5) Symptoms of anemia ... marrow failure with anemia ... #oncology #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... skin that are caused ... Chronic Myelogenous Leukemia ... Leukemia • Idiopathic ... Syndromes #diagnosis #hematology
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... hair follicles -> causes ... UV light Incr cell ... Manifestations #pathophysiology ... #diagnosis #signs
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Responsive to Treatment ... Treated Like Acute Leukemias ... growth, response to treatment ... Classification #pathophysiology ... #Hematology #Diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... and petechiae Causes ... virus (EBV) • Leukemia ... Treatment: ... #oncology #hematology
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