12 results
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
, APML, CLL Acute ... ALL (Acute Lymphoblastic ... Transformation: • Complication ... #Hematology #Oncology ... #Diagnosis
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
with no early symptoms ... ’s lymphoma or acute ... complications: ... #diagnosis #workup ... #oncology #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
minimal tumor burden Diagnosis ... lymphocytes, smudge cells ... thrombocytopenia Complications ... #oncology #hematology ... #hemeonc #diagnosis
Acute Rheumatic Fever: Pathogenesis and Clinical Findings

Delayed autoimmune reaction
-> Molecular mimicry
-> GAS antigen cross-reacts with host
->
Acute Rheumatic ... B and CD-4+ T cells ... RheumaticFever #pathophysiology ... #diagnosis #signs ... #symptoms #complications
Acute Otitis Media: Complications
Infection and inflammation of the middle ear
 - Prolonged obstruction of e. tube
Acute Otitis Media ... to mastoid air cells ... #pathophysiology ... #symptoms #signs ... #diagnosis
Retinoblastoma: Pathogenesis and clinical findings
 • Sporadic mutation -> One allele of RB1 tumor suppressor gene
mutated in all cells ... / Complications ... Retinoblastoma #pathophysiology ... #ophthalmology ... #diagnosis #signs
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
- Differential Diagnosis ... pattern of spread, B symptoms ... Treated Like Acute ... Leukemias, very ... Classification #pathophysiology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
ATRA treatment Pathophysiology ... Release from blast cells ... • Rare: DAH, acute ... : >3 symptoms, or ... management #hematology #oncology
Central Retinal Artery Occlusion: Pathogenesis and clinical findings
 • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
Disease: (i.e. leukemia ... trucking" • Acute ... #ophthalmology ... #diagnosis #signs ... #symptoms
Mastoiditis: Pathogenesis and clinical findings

Acute or Chronic Otitis Media -> 
Stage 1: Hyperemeia of the mastoid
clinical findings Acute ... the mastoid air cells ... #Mastoiditis #pathophysiology ... #signs #symptoms ... #diagnosis #otology