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hematology oncology management differential leukemia acidosis apl aplastic auerrods bloodsmear causes chronic classification clinical cll elevation lactate lactic lymphocytic mds
A 37-year-old woman initially presented with pancytopenia and found to have leukopenia (2.1 × 103/μL) with
promyelocytes, anemia ... She was diagnosed ... hospitalization and treatment ... #Clinical #Path ... #Smear #Microscopy
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 Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
factor (GCSF) treatments ... abnormal under a microscope ... marrow studies Treatment ... Immunosuppressive treatment ... #diagnosis #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Constitutional Syndromes ... Treatment: ... result from low blood ... oncology #hematology #diagnosis
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Age: 50-60 • Auer ... develop leukostasis syndrome ... - infiltrates (anemia ... • Tumor lysis syndrome ... Hematology #Oncology #Diagnosis
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
polyangiitis), MPA (microscopic ... reveals increasing blood ... FINDINGS: • U/A: microscopic ... proteinuria • Path ... #management #treatment
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
phenomenon CLL Diagnosis ... Lymphocytosis: Absolute blood ... • Neutropenia, anemia ... microglobulin Treatment ... • Richter’s Syndrome
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Diagnosis: • Dry ... RTA, TYPE I RTA Diagnosis ... Pulmonary amyloidosis, PAH ... Adenocarcinoma Treatment ... lubricants • Pharmacologic
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
removal from the blood ... e.g., uptake by cells ... before beginning treatment ... - Compartment syndrome ... 30mmHg) - Severe anemia
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