8 results
hematology oncology algorithm autoinflammatory causes cell clinical differential e1 electrophoresis elevatedmcv gammopathy indications largegranular leukemia lymphocytic macrocytic macrocytosis management mgus
Multiple Myeloma Diagnosis and Management Summary Clinical Signs: • hyperCalcemia 28% (bone demineralization) • Renal disease 48%
Multiple Myeloma ... hypercalcemia) • Anemia ... osteolytic lesions and pathologic ... marrow plasma cells ... #Myeloma #Diagnosis
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
Abnormalities: macrocytic anemia ... thrombocytopenia, multiple ... myeloma, myelodysplastic ... hematologic conditions - multiple ... cells NEJM Review
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
- Differential Diagnosis ... Formation • Multiple ... Myeloma Dysplastic ... Macrocytosis, Target Cells ... #Differential #Diagnosis
Indications for Serum Protein Electrophoresis (SPEP) • Suspected multiple myeloma, Waldenström's macroglobulinemia, primary amyloidosis, or related
• Suspected multiple ... myeloma, Waldenström's ... • New-onset anemia ... • Unexplained pathologic ... SPEP #Hematology #Diagnosis
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
No evidence of anemia ... progress to IgM multiple ... insufficiency, Anemia ... progression to multiple ... Significance #hematology #diagnosis
T-LGL leukemia - T-CeIl Large Granular Lymphocytic Leukemia Clinical - Persistent (>6mo) lymphocytosis (2-20k) with proven clonality
required for dx - T-cells ... Neutropenia (85%), anemia ... are NK cells (sCD3 ... Lymphocytic #Leukemia #hemepath ... #pathology #diagnosis
Raindrop Skull- ...A skeletal survey showed diffuse osteopenia, a pubic bone fracture, and numerous radiolucent lesions
myeloma. ... The diagnosis was ... clonal plasma cells ... #NEJM #clinical ... #myeloma
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
Diagnosis? ... • No CRAB - no anemia ... patients with EMD myeloma ... IFE, FLC assay Pathology ... • Multiple myeloma
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