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diagnosis algorithm differential oncology causes clinical path smear dermatology generalized pruritus secondary systemic agglutinin aplastic asplenia atlas autoinflammatory cancer chronic
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... , Liver diseases ... Myelodysplastic syndrome ... Hemolytic uremic syndrome ... #differential #hematology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
thromboembolic disease ... vasculitis • Hematologic ... Abnormalities: macrocytic anemia ... including peripheral blood ... NEJM Review: https
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... develop leukostasis syndrome ... - infiltrates (anemia ... • Tumor lysis syndrome ... #Hematology #Oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia ... Myeloproliferative Disease ... cells, red blood ... #diagnosis #hematology
Schistocytes - The arrows point to schistocytes which are fragmented red blood cells. Also called schizocytes,
fragmented red blood ... In the right photo ... hemolytic- uremic syndromes ... Clinical #Path #BloodSmear ... #Blood #Smear #
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
can indicate disease ... Lymphocytosis: Absolute blood ... • Neutropenia, anemia ... • Sezary syndrome ... workup #oncology #hematology
Sickle cells These photos show sickle cells on peripheral blood smears. In the left photo target cells
blood smears. ... to sickle cell disease ... no significant anemia ... Clinical #Path #BloodSmear ... #Blood #Smear #
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Algorithm Normal Blood ... Myelodysplastic Syndromes ... Macrocytosis, Target Cells ... • Liver Disease ... Algorithm #Causes #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Constitutional Syndromes ... virus (EBV) • Leukemia ... result from low blood ... #oncology #hematology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
/ Systemic == Blood ... renal failure/uremia ... • Lymphoma • Leukemia ... Myelodisplastic syndrome ... Psychiatric Disease
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