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diagnosis clinical hematology smear bloodsmear differential path oncology algorithm causes dermatology generalized laboratory lactate management mds myelodysplastic peripheral pruritus secondary
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
the peripheral blood ... - Blood and Bone ... develop leukostasis syndrome ... - infiltrates (anemia ... • Tumor lysis syndrome
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia ... cells, red blood ... cells - red blood ... cells, white blood
Plasmacytomas and Plasma-Cell Leukemia - Physical examination revealed multiple exophytic subcutaneous lesions involving the arms and
and Plasma-Cell Leukemia ... A peripheral-blood ... revealed 25% plasma cells ... Plasmacytomas #PlasmaCell #Leukemia ... #Smear #NEJM
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... Myelodysplastic syndrome ... • Sickle cells ... alcoholism • Burr cells ... Hemolytic uremic syndrome
Dacrocytes (tear drop cells) Other poikilocytes resemble a pear or teardrop. The narrow, tapered end may be
Dacrocytes (tear drop cells ... each of the above photos ... metaplasia, pernicious anemia ... some hemolytic anemias ... Path #BloodSmear #Blood
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Constitutional Syndromes ... marrow-failure syndromes ... virus (EBV) • Leukemia ... result from low blood
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
or basket cells ... Lymphocytosis: Absolute blood ... • Neutropenia, anemia ... • Richter’s Syndrome ... • Sezary syndrome
Spur-Cell Anemia- A 31-year-old man with a history of cirrhosis, recurrent hepatic encephalopathy, and anemia presented
..A peripheral-blood ... Spur cells acquire ... resolve despite blood ... #NEJM #clinical ... #peripheral #blood
Schistocytes - The arrows point to schistocytes which are fragmented red blood cells. Also called schizocytes,
fragmented red blood ... In the right photo ... seen in hemolytic anemias ... hemolytic- uremic syndromes ... Path #BloodSmear #Blood
Codocytes (Target cells) - Two target cells are seen in the left photo and one in
) - Two target cells ... seen in the left photo ... present in the left photo ... with hemolytic anemias ... Path #BloodSmear #Blood
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