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diagnosis hematology oncology anemia autoinflammatory chronic cll lymphocytic management mds myelodysplasia myelodysplastic rheumatology somatic syndromes vacuoles vexas workup xlinked
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
VEXAS (Vacuoles, E1 ... • UBA1 = major E1 ... including peripheral ... blood myeloid cells ... NEJM Review: https
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Constitutional Syndromes ... virus (EBV) • Leukemia ... anemia) Labs: • Peripheral ... result from low blood
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
cytometry • Peripheral ... Lymphocytosis: Absolute blood ... Pure red cell aplasia ... • Richter’s Syndrome ... • Sezary syndrome
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
bone marrow and peripheral ... leukopenia) Peripheral ... Causes • Anemia • Aplastic ... Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia
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