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diagnosis apml causes coagulation dic differentiation disseminated hemeonc hemophagocytic hlh intravascular leukostasis lymphohistiocytosis lysis oncology rheumatology tafro thrombocytopenia tls treatment
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... + lab signs of end ... Lysis of tumor cells ... TLS #diagnosis #management ... #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... ATRA treatment Pathophysiology ... Diagnosis: >3 symptoms ... APML #diagnosis #management ... #hematology #oncology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
protein C and S Pathophysiology ... Fibrinolysis → End ... Schistocytes, helmet cells ... causes #treatment #management ... #hematology
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
overgrowth of cells ... cell lymphoma Pathophysiology ... and the systemic symptoms ... TAFRO #diagnosis #management ... #rheumatology #
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... hyperinflammatory syndrome ... Common Signs and Symptoms ... Pathophysiology ... #Hematology #HemeOnc
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