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diagnosis management oncology rheumatology causes differential chronic cll disease hemolytic leukemia lymphocytic syndrome acidosis agglutinin algorithm aplastic arteritis ascorbicacid autoinflammatory
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... cells can infiltrate ... • Neutropenia, anemia ... microglobulin Treatment ... #oncology #hematology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
recurrent fevers, vasculitis ... • Hematologic ... Abnormalities: macrocytic anemia ... hematopoietic stem cells ... blood myeloid cells
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Algorithm • Sickle cells ... cardiac valve, vasculitis ... Diagnosis #Algorithm #workup ... #hematology #testing
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... factor (GCSF) treatments ... Workup: • Complete ... marrow studies Treatment ... Syndromes #diagnosis #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
lymphocytes, smudge cells ... immunophenotype Clinical ... 5) Symptoms of anemia ... marrow failure with anemia ... Leukemia #oncology #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
hematopoietic stem cells ... number of CD34+ cells ... cellularity + dysplastic cells ... number of CD34+ cells ... Number of CD34+ cells
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
from mature B cells ... Hodgkin Lymphoma - Clinical ... Hodgkin Lymphoma Workup ... Hodgkin Lymphoma Treatment ... #hematology #oncology
Scurvy (Vitamin C Deficiency) - Diagnosis and Management Vitamin C is required for hydroxylation of proline residues
poor nutrition Clinical ... breath, wasting, anemia ... Loss of teeth Anemia ... integrity of the cell ... Treatment:
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... Viral Infection Clinical ... • Symptoms of anemia ... sensitize red blood cells ... #hematology #diagnosis
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
Related Disease Clinical ... No necrosis, No vasculitis ... increased IgG4+ cells ... management #phenotypes #workup ... #treatment #rheumatology
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