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diagnosis nephrology chloride differential management syndrome alkalosis epilepticus hypochloremia metabolic pediatrics peds seizure urinary urine
Gitelman Syndrome Pathophysiology Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Pathophysiology ... recessive salt-losing ... thiazide-sensitive sodium-chloride ... H+ secretion → Hypokalemia ... #nephrology #diagnosis
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
salt-losing tubulopathies ... thiazide-sensitive sodium ... thiazide-sensitive sodium ... alkalosis • Normal or low ... #management #pathophysiology
Hypochloremia - Differential Diagnosis Algorithm Cause - Decreased Intake: • Low salt in diet • Exclusive D5W
Differential Diagnosis Algorithm ... Decreased Intake: • Low ... - Bartter - Gitelman ... altered mental status ... #Pathophysiology
Metabolic Alkalosis - Urinary Chloride Algorithm Cl- responsive metabolic alkalosis • Kidney loss of Cl-
Urinary Chloride Algorithm ... alkalosis • Normal/low ... Bartter syndrome, Gitelman ... Normal acid-base status ... the excretion of sodium
Management of Convulsive Status Epilepticus in children Stabilization Phase (Seizure 0-5 minutes): • Check and maintain ABC
of Convulsive Status ... • Give high flow ... IV Thiopental Sodium ... seizure #Management #neurology ... pediatrics #peds #algorithm
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