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diagnosis dermatology classification causes cutaneous dermatologic management petechiae petechial physicalexam polyangiitis prs pulmonary rapidly renal rpgn skin syndromes treatment types
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Negative IF): • PR3-ANCA ... (C-ANCA): GPA > ... MPO-ANCA (P-ANCA ... #Vasculitis #differential ... #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
proteinuria, rapidly progressing ... Vasculitis: + MPO-ANCA ... mucositis - Rash ... Serologies for Cryoglobulins ... #rheumatology #
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Skin ulcers - Glomerulonephritis ... triad of Palpable ... DDX: • ANCA (Antineutrophil ... - GPA, EGPA, microscopic ... classification #rheumatology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
reticularis Differential ... purpura • Mixed cryoglobulinemia ... • Goodpasture syndrome ... #dermatology #rash ... #diagnosis #rheumatology
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
Vessel: Petechiae, Palpable ... ANCA Associated: ... - Microscopic ... - GPA Cutaneous ... #rheumatology #
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... , mucositis • Rash ... )): Microscopic ... MPO > PR3 60/ GPA ... Diagnosis #Rheumatology
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
- Differential ... RA, Sjogren's, GPA ... , EGPA, Microscopic ... Measurement of antinuclear ... immunoglobulins & cryoglobulins
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Summary Autoimmune ANCA ... ): GPA (granulomatous ... • Cutaneous: palpable ... Auto-antibodies: ANCA ... Path: rapidly progressive
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