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management blood differential syndrome vasculitis activation algorithm clinical disorders dress eosinophilia hand lcv leukocytoclastic macrophage mas photo transfusion transfusions vancomycin
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... allergy, drug reaction ... signs or symptoms (eg ... #Differential #diagnosis ... #hematology #eosinophilia
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Definition: • Severe adverse drug reaction, characterized by
extensive skin rash ... Criteria for Diagnosis ... • SJS/TEN • Acute ... DRESS #Syndrome #dermatology ... #diagnosis #management
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Types: • Leukocyte ... maculopapular rash ... proteins on plts, leukocytes ... #Transfusions #diagnosis ... #management #hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
maculopapular rash ... proteins on plts, leukocytes ... Blood products contain ... #Transfusion #diagnosis ... #management #hematology
Vancomycin induced Leukocytoclastic Vasculitis (LCV) of the Hand 70 M vertebral osteomyelitis on vancomycin and cefepime for
diffuse palpable rash ... Diagnosis? ... includes drug reaction ... with eosinophilia ... #dermatology #clinical
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Petechial or purpuric rash ... Fibrin degradation products ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
disease, drug reactions ... arthralgia, arm/leg ... , mucositis • Rash ... Polyangiitis): • Eosinophilia ... #Rheumatology
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