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diagnosis hematology blood product activation bleeding common cvid disorders hemophilia immunodeficiency immunology leukemia macrophage oncology pediatrics primarycare transfusion transfusions treatment
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
with CVID have a history ... Lymphoma or other cancers ... gastric and breast cancer ... severe community-acquired ... #immunology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
ALL: mediastinal mass ... • Tumor lysis syndrome ... lymphoid organs When Cancer ... Agranulocytosis • Hypogammaglobulinemia ... #Leukemia #Hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Product Types: • Leukocyte ... maculopapular rash ... proteins on plts, leukocytes ... Transfusions #diagnosis #management ... #hematology #reactions
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Blood Transfusion Reactions ... maculopapular rash ... proteins on plts, leukocytes ... Transfusion #diagnosis #management ... #hematology #reactions
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
Consistent bleeding history ... mixing study (aPTT may ... hemophilia treatment center ... Avoid meds that ... #treatment #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
(MAS) Classified ... the secondary or acquired ... Petechial or purpuric rash ... #Diagnosis #Management ... #Hematology #Rheumatology
Helpful Clinical Features in Evaluating Bleeding Disorders Age of onset • Neonate - in 20% of haemophilias,
— haemophilias may ... bleeding tendency is acquired ... Marfan syndrome, ... #peds #pediatrics ... #diagnosis #hematology
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