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differential management neurology classification guillain hematology anemia aplastic cryofibrinogenemia cryoglobulins dermatologic dermatology gbs gpa granulomatosis guillainbarre inflammatory iris manifestations myelitis
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Syndrome: • Clinical ... HCV infection, ... HBV infection, HIV ... • Vasculitis ... #vasculitis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... to exclude are infections ... Presentation - Systemic Symptoms ... Cryoglobulins • HIV ... #rheumatology #
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Presentation: Systemic Symptoms ... • Progressive symptoms ... tract, and often causes ... / ANCA + MPO) Cryoglobulinemic ... #Rheumatology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
vasculitis Skin ... : Vasculitis: ... Granulomatous vasculitis ... • Necrotising vasculitis ... leukocytoclastic vasculitis
Guillain-Barre Syndrome - Summary Acute AIDP that presents with rapidly progressive flaccid weakness Epidemiology: • 1-2 cases/100,000 per
Guillain-Barre Syndrome ... Summary Acute AIDP ... Pathophysiology: • Immune ... response preceding infection ... #Syndrome #diagnosis
Guillain-Barré Syndrome (GBS) Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness Epidemiology: • Incidence: 1
Guillain-Barré Syndrome ... Incidence: 1 to 2 cases ... immunodeficiency virus (HIV ... than one after symptom ... #Syndrome #diagnosis
Neurological Manifestations of Tuberculosis Spinal Arachnoiditis & Polyradiculopathy: • Subacute onset of limb weakness, bladder/bowel dysfunction, muscle
Reconstitution Inflammatory Syndrome ... (IRIS): • In HIV ... Meningitis • Include: vasculitis ... • Caused by immune ... #Tuberculosis #diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia Clinical ... and petechiae Causes ... - HIV • Immune ... CMV) • Epstein-Barr ... #diagnosis #management
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Cryofibrinogenemia Symptoms ... malignancies, vasculitis ... Malignancy • Infections ... cryoglobulins • Negative causes ... Antiphospholipid syndrome
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
Inflammatory Syndrome ... /AIDS patients ... be present: • AIDS ... initiation Clinical ... albicans • Epstein Barr
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