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differential management oncology leukemia product reactions anemia cbc chronic classification cll hemolytic lymphocytic lymphoma neutrophil pathophysiology petechiae petechial physicalexam rash
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Dyspnea • Fever ... Lymphoma Workup ... : • Full Blood ... number of sites of disease ... classification #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Algorithm • Sickle ... vasculitis, malignant hypertension ... bartonella (oroya fever ... #Algorithm #workup ... #hematology #testing
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Red Flags: • Fever ... appearance • Hypotension ... deficiency Work ... #Algorithm #Causes ... #dermatology #physicalexam
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... -> AML: Blast crises ... Headaches, bone pain, fever ... #Leukemia #Hematology ... #Oncology #Diagnosis
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
leukocytes. ... • Autoimmune diseases ... tachycardia or fever ... bacteremia and hypotension ... neutrophil #WBC #CBC #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
activity is the diagnostic ... hallmark for the disease ... of Peripheral blood ... a left shift Urinalysis ... #Workup #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphadenopathy • Fevers ... cells can indicate disease ... Lymphocytosis: Absolute blood ... #workup #oncology ... #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Product Types: • Leukocyte ... proteins on plts, leukocytes ... bleeding - Hypotension ... #Transfusions #diagnosis ... #management #hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
S/sx: Fever, flank ... proteins on plts, leukocytes ... ↑bleeding • Hypotension ... #Transfusion #diagnosis ... #management #hematology
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