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diagnosis differential management oncology causes cellulitis classification clinical common cvid dermatology gap globulin hemolysis hepatitis hodgkins hypogammaglobulinemia immunodeficiency immunology infection
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Algorithm and Causes ... Increased red cell ... #Hemolytic #Anemia ... #Causes #Workup ... #Hematology #Diagnosis
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Differential Diagnosis Algorithm ... • Sickle cells ... Consider sickle cell ... #workup #hematology
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... corpuscular (cell ... Red cell distribution ... acute blood loss, hemolysis ... #Workup #Hematology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... breast CA, small cell ... hepatitis: < 1 • Cirrhosis ... differential #diagnosis #algorithm ... #hepatology
Vibrio Vulnificus skin infection Cirrhosis w/recent consumption of raw oysters w/rapidly evolving rash. Vibrio vulnificus part of
skin infection Cirrhosis ... necrotic ulcers Risk ... hemochromatosis, hemolytic ... anemia, CKD, hiv ... immunosuppressive meds
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Differential Diagnosis Algorithm ... circulation = risk ... Better call hematology ... you’ll do a good workup ... #workup #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
increased infection risk ... to impaired B-cell ... anemia) • Systemic ... Low serum IgG level ... hypogammaglobulinemia #immunology #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Hodgkin Lymphoma Risk ... nodosum • Immune hemolytic ... anemia • Pain ... Hodgkin Lymphoma Workup ... classification #hematology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
bone marrow at a level ... • No CRAB - no anemia ... involvement - higher risk ... Oncology #Diagnosis #Workup ... #Hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... disease: Cirrhosis ... gastric tumors • Hematology ... anemia • Other ... differential #diagnosis #hematology
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