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diagnosis hematology systemic abnormal coagulation generalized prolonged pruritus pt bleeding bruising disorders hemostasis immunecompromised immunocompromised naildisorders nonpalpable palpable petechiae petechial
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Early liver disease ... Reduced liver synthesis ... #diagnosis #differential ... #hematology #coagulation
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... (e.g. heparin contamination ... thrombin inhibitors, heparin ... • Reduced liver ... #hematology #coagulation
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Diagnosis Algorithm ... Diabetes Mellitus Liver ... • Cholestatic liver ... Pruritus #primary #secondary ... #generalized #dermatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Platelet Disorders - Differential ... : INR/PT, aPTT(liver ... (CVID, WAS), (neurologic ... bypass), LFT (liver ... #Workup #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... leakage of RBC's secondary ... deficiency • Liver ... mountain spotted fever ... #nonpalpable #dermatology
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Nail Disorders secondary ... discoloration) • Liver ... #dermatology #Differential ... #Diagnosis #Algorithm ... #causes
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Diabetes Mellitus Liver ... • Cholestatic liver ... #Pruritus #secondary ... #generalized #dermatology ... #causes
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
Acquired: • Heparin ... deficiency • Liver ... suggests liver ... are liver function ... Acquired: • Liver
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Rash - Differential ... in primary or secondary ... Red Flags: • Fever ... #Causes #dermatology
Causes of Fever in the Immunocompromised Host - Differential Diagnosis Algorithm Structural Defect - Asplenia/HypospIenism • Bacteremia/Septic
Causes of Fever ... Diagnosis Algorithm ... • Bacteremia/Septic ... Infection #Fever ... #Causes #Hematology
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