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diagnosis hematology algorithm causes leukemia lymphoma management aplastic cell chronic classification cll comparison disorders hemolytic lymphocytic mds myelodysplasia myelodysplastic nonhodgkins
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
- Pel-Ebstein fever ... involvement Differential ... NonHodgkins #comparison #oncology ... #diagnosis #differential ... #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Dyspnea • Fever ... Weight loss • Anemia ... Lymphoma Workup ... Immunohistochemical studies (to differentiate ... #oncology #management
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Rash - Differential ... Red Flags: • Fever ... deficiency Work ... • Abdominal ultrasound ... Algorithm #Causes #dermatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Presentation: • Fever ... recurrent infections/fevers ... bleeding, and petechiae ... index < 2 • EPO Level ... #oncology #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... bartonella (oroya fever ... Diagnosis #Algorithm #workup ... #hematology #testing
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Platelet Disorders - Differential ... Diagnosis and Workup ... History of bleeding (petechiae ... changes), high MCV anemia ... #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
identical to the non-Hodgkin ... Lymphadenopathy • Fevers ... • Neutropenia, anemia ... Leukemia #diagnosis #workup ... #oncology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Headaches, bone pain, fever ... Significant ↓ PLT: Petechiae ... - infiltrates (anemia ... Lymphadenopathy • HSM • Fevers ... #Oncology #Diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... caused by bleeding (petechiae ... Workup: • Complete ... blood count with differential ... #oncology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
bone marrow at a level ... • No CRAB - no anemia ... macroglobulinemia • Non-Hodgkin ... #Plasmacytoma #Oncology ... #Diagnosis #Workup
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