14 results
Hemophagocytic Lymphohistiocytosis (HLH)
Clinical Features: Fever, Splenomegaly, Hepatomegaly, Lymphadenopathy, Confusion
Classic lab findings in HLH: ↑↑ ferritin, Anemia,
Hemophagocytic Lymphohistiocytosis ... Features: Fever, ... : • Fever • Splenomegaly ... #Hemophagocytic ... Lymphohistiocytosis #diagnosis #hematology
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Hemophagocytic Lymphohistiocytosis ... signs and symptoms ... following: • Fever ... #Hemophagocytic ... management #treatment #hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
disease • Periodic fever ... multiorgan failure • Fever ... - Nonremitting fever ... Diagnosis #Management #Hematology ... #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Diagnostic Criteria - 2004 vs 2009

At least three of the following: 
 -
(HLH) Diagnostic ... Criteria - 2004 ... following: - Fever ... #Hemophagocytic ... #Hematology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Hemophagocytic Lymphohistiocytosis ... • Clinical: fever ... , ↓ Fibrinogen level ... #Hemophagocytic ... treatment #summary #rheumatology
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Disorders Testing Algorithm ... evaluation or workup ... 1,500 cells/µL Workup ... organ-specific signs ... Differential #diagnosis #hematology
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
: ARDS Berlin Criteria ... without other cause ... explain symptoms • Fever ... pulmonary edema) • Fever ... Transfusion #Reactions #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Differential Diagnosis Algorithm ... bartonella (oroya fever ... Differential #Diagnosis #Algorithm ... #workup #hematology
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
of about three cases ... • Dyspnea • Fever ... Hodgkin Lymphoma Workup ... through Ann Arbor criteria ... classification #hematology
Polycythemia - Differential Diagnosis Algorithm
Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Differential Diagnosis Algorithm ... an underlying cause ... Better call hematology ... you’ll do a good workup ... #workup #hematology