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diagnosis hematology leukemia american chagas chronic cll hemeonc hemophagocytic hlh lymphocytic lymphohistiocytosis microbiology product reactions trypanosomiasis algorithm anemia aplastic classification
"Initial management of FEBRILE NEUTROPENIA. Adapted from the 2011 Infectious Diseases Society of America guidelines"-McMaster Textbook
"Initial management ... 2011 Infectious Diseases ... #Febrile #Fever ... #Neutropenic #Management ... #Algorithm #InfectiousDiseases
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Presentation: • Fever ... index < 2 • EPO Level ... result from low blood ... Aplastic #Anemia #oncology ... #management
Chagas Disease (American trypanosomiasis) - Diagnosis and Management Summary Acute Chagas Disease (8-12 weeks): • Mild: Malaise,
Diagnosis and Management ... Mild: Malaise, fever ... detectable by blood ... trypanosomiasis #Diagnosis #Management ... #Microbiology #InfectiousDiseases
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
respiratory symptoms • Fever ... pulmonary symptoms • Rheumatologic ... infection • Cough, fever ... • Isolated fever ... Fungal #Diagnosis #Management
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Phagocytosis of blood ... • Clinical: fever ... , ↓ Fibrinogen level ... Lymphohistiocytosis #diagnosis #management ... treatment #summary #rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... Headaches, bone pain, fever ... or functional neutropenia ... Lymphadenopathy • HSM • Fevers ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
) B symptoms → fevers ... PRCA, autoimmune neutropenia ... chemotherapy for low-risk disease ... Lymphocytic #Leukemia #oncology ... #diagnosis #management
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
S/sx: Fever, flank ... have drop in Hct, fever ... Sx include: fever ... Transfusion #diagnosis #management ... #hematology #reactions
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
S/sx: Fever, flank ... have drop in Hct, fever ... Sx include: fever ... Transfusions #diagnosis #management ... #hematology #reactions
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphadenopathy • Fevers ... cells can indicate disease ... Lymphocytosis: Absolute blood ... Cytopenias: • Neutropenia ... diagnosis #workup #oncology
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