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diagnosis differential dermatology management oncology secondary systemic classification generalized infectiousdiseases rheumatology acidosis activation acute aplastic cardiology chronic ckd elevatedmcv elevation
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Pruritus - Generalized ... Diabetes Mellitus Liver ... • Cholestatic liver ... Myelodisplastic syndrome ... #causes
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... WBCs - Normal Liver ... Deficiency - Abnormal Liver ... Tests • Liver ... #Causes #Hematology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Diabetes Mellitus Liver ... • Cholestatic liver ... renal failure/uremia ... Myelodisplastic syndrome ... #causes
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
disease • Periodic fever ... multiorgan failure • Fever ... - Nonremitting fever ... with leukopenia, anemia ... thrombocytopenia • Liver
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Hemolytic anemia ... Kasabach-Merritt syndrome ... deficiency • Liver ... Gardner-Diamond syndrome ... mountain spotted fever
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Causes of Fatigue ... Renal Failure • Liver ... Neoplastic / Hematologic ... • Anemia • ... Chronic Fatigue Syndrome
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Presentation: • Fever ... and petechiae Causes ... index < 2 • EPO Level ... Treatment: ... #oncology #hematology
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Iron deficiency anemia ... discoloration) • Liver ... • Nephrotic syndrome ... Differential #Diagnosis #Algorithm ... #causes
Acute Retroviral Syndrome Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection •
Headache (45%) • Fever ... Hepatomegaly - Liver ... • Viral RNA level ... subset counts ↓ • Liver ... enzymes ↑ • Mild anemia
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
glucose by the liver ... contribution of liver ... - Compartment syndrome ... mellitus/DKA - Liver ... gluconeogenesis Liver
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