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diagnosis management hematology cardiology differential erythematosus lupus sle activetb infectiousdiseases latenttb leukemia signs symptoms syndrome tb tuberculosis activation autoantibodies calcium
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features of Systemic ... (SLE) General: Fever ... effusion, Restrictive lung ... Pericarditis, Endocarditis ... symptoms #diagnosis #rheumatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... Subacute-Acute: • Common: fever ... common • Imaging: CXR ... Renal Failure Treatment ... #oncology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
disease • Periodic fever ... multiorgan failure • Fever ... - Nonremitting fever ... rash) • Heart, lung ... #Rheumatology
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Hyperthyroidism Fever ... • Rheumatic fever ... SLE, Rheumatic fever ... • New murmur, fever ... , Rheumatic fever
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Malar rash 40% - Fever ... Myositis 4% - Lung ... Lupusreference #SLE #Systemic ... #differential #rheumatology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
Neutropenic fever ... : - Fever + ANC ... interventional radiology ... or HSCT - CRS: fever ... therapy - Symptoms: fever
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Headaches, bone pain, fever ... manifestations, hypoxia, CXR ... smear: Blasts APML ... Lymphadenopathy • HSM • Fevers ... #Oncology #Diagnosis
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
verrucous) • Lung ... night sweats, fever ... Vascular: • Systemic ... underlying cause + Systemic ... Persistent bacteremia/fevers
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
respiratory symptoms • Fever ... pulmonary symptoms • Rheumatologic ... infection • Cough, fever ... • Isolated fever ... arthritis, and endocarditis
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
Active TB: • Fever ... and Culture • CXR ... Tuberculosis Treatment ... Initiating Treatment ... disease • Check CXR
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