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diagnosis hematology aplastic differential gammopathy gap leukemia management mgus plasmacytoma protein proteingap significance solitary undetermined workup
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
No evidence of anemia ... marrow plasma cells ... insufficiency, Anemia ... #Significance #hematology ... #diagnosis #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Presentation: • Fever ... number of CD34+ cells ... index < 2 • EPO Level ... antithymocyte globulin ... #oncology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Headaches, bone pain, fever ... , weight loss, abdominal ... - infiltrates (anemia ... #Leukemia #Hematology ... #Oncology #Diagnosis
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Causes of Monoclonal ... myeloma • Plasma cell ... Sarcoidosis) • Liver ... Thalassemia, Sickle cell ... anemia • Other
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
tissue composed of monoclonal ... bone marrow at a level ... • No CRAB - no anemia ... #Plasmacytoma #Oncology ... Diagnosis #Workup #Hematology
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