6 results
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
40 ml/min A - Anemia ... marrow plasma cell ... • CML, B and T cell ... , amyloidosis, solitary ... #oncology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
No evidence of anemia ... marrow plasma cells ... insufficiency, Anemia ... #Significance #hematology ... #diagnosis #oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
myeloma • Plasma cell ... leukemia • Solitary ... Sarcoidosis) • Liver ... Thalassemia, Sickle cell ... anemia • Other
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Presentation: • Fever ... number of CD34+ cells ... index < 2 • EPO Level ... antithymocyte globulin ... #oncology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
Headaches, bone pain, fever ... , weight loss, abdominal ... - infiltrates (anemia ... #Leukemia #Hematology ... #Oncology #Diagnosis
Solitary Cell Plasmacytoma

What?
• Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma)
• In 3%
Solitary Cell Plasmacytoma ... tissue composed of monoclonal ... bone marrow at a level ... • No CRAB - no anemia ... #Oncology #Diagnosis