26 results
Drug-Induced Liver Injury - Pathophysiology
Indirect
Idiosyncratic
Direct

BWH Medicine Chiefs @BrighamChiefs

#DILI #DrugInduced #Liver #Injury #Pathophysiology #hepatology
Drug-Induced Liver ... Injury - Pathophysiology ... #DrugInduced #Liver ... #Injury #Pathophysiology ... #hepatology
Acute Spinal Cord Injuries: Pathogenesis and clinical findings
 • Anterior Cord Syndrome -> Anterior spinal artery
level. ... motor function, level ... Syndromes #diagnosis #pathophysiology ... #signs #symptoms ... #msk #orthopedics
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic Liver ... months without treatment ... disease, liver ... Injury (DILI) ... Failure #Cirrhosis #Hepatology
Lelli's Test (Lever Sign) for ACL Injury

A fist is placed under the proximal 3rd of the
Lelli's Test (Lever ... Sign) for ACL Injury ... #Lellis #Test #Lever ... #Sign #ACL #Injury ... physicalexam #sports #msk
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Drug Induced Liver ... non-essential drug/HDS treatments ... Alcohol-related liver ... #DrugInduced #Liver ... #Algorithm #hepatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
65 years PBC Pathophysiology ... cholestasis → Cirrhosis/Liver ... failure PBC Signs ... or higher • Liver ... #hepatology
Hepatitis B - Treatment Indications
Treatment not indicated:
 • Immune tolerant state - HBe-Ag detectable, high HBV
Hepatitis B - Treatment ... infection with severe liver ... injury (INR > 2 ... mg/dL) or acute liver ... Indications #management #hepatology
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
disease to acute liver ... hepatocellular pattern of liver ... injury, though ... regarding need for treatment ... Diagnosis #Management #Hepatology
Heat Illnesses and Heat Stroke - Differential Diagnosis Framework

Heat Cramps:
 • Muscle pain or spasm -
Muscles, Kidneys, Liver ... Rhabdomyolysis - AKI - Liver ... Collapse: • Pathophysiology ... → Syncope • Signs ... tissue damage (AKI, Liver
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Diagnosis: HLH signs ... lymph node, or liver ... • Bicytopenia Treatment ... diagnosis #management #treatment ... #hematology