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diagnosis hematology differential management hodgkins leukemia workup aplastic cell chronic classification cll common cvid erythematosus gap globulin hypogammaglobulinemia immunodeficiency immunology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
- Comparison ... the spleen or liver ... #NonHodgkins #comparison ... #oncology #diagnosis ... #differential #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Presentation: • Fever ... Constitutional Syndromes ... index < 2 • EPO Level ... #oncology #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Dyspnea • Fever ... Weight loss • Anemia ... Immune hemolytic anemia ... classification #hematology ... #oncology #management
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
• Neutropenia, anemia ... • Richter’s Syndrome ... leukemia • Sezary syndrome ... diagnosis #workup #oncology ... #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Marginal Zone Lymphoma ... Marginal zone lymphoma ... (-) hemolytic anemia ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
hepatitis • Lymphoma ... • Nodules • Lymphoid ... autoimmune hemolytic anemia ... Low serum IgG level ... hypogammaglobulinemia #immunology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
develop leukostasis syndrome ... - infiltrates (anemia ... • Tumor lysis syndrome ... #Leukemia #Hematology ... #Oncology #Diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Non-autoimmune rheumatologic ... Angioimmunoblastic T-cell lymphoma ... pneumonitis • Diffuse ... enteropathy, and diffuse ... lymphopenia, low PLT • Anemia
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Amyloidosis • Lymphoma ... changes (POEMS syndrome ... gastric tumors • Hematology ... Thalassemia, Sickle cell anemia ... differential #diagnosis #hematology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
bone marrow at a level ... • No CRAB - no anemia ... • Non-Hodgkin Lymphoma ... #Plasmacytoma #Oncology ... Diagnosis #Workup #Hematology
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