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diagnosis liver differential algorithm druginduced function hepatocellular interpretation tests causes chemistry cholestatic drug elevation enzymes functiontest gastroenterology hepatitis idiosyncratic induced
Drugs and Classes Associated with DILI and Type of Liver Injury #Medications #Differential #DrugInduced #LiverInjury #Hepatology #Pharmacology
Associated with DILI ... and Type of Liver ... Injury #Medications ... #LiverInjury #Hepatology ... #Pharmacology #
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 Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - ... (>1000): • DILI ... injury) • Ischemic ... Differential #Diagnosis #hepatology ... #transaminitis
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Enzymes (LFTs ... Liver Injury ... pathology (low level ... #Cholestatic #Transaminitis ... #differential #hepatology
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
(LFTs) Elevation ... abnormality vs bone Bili ... #FunctionTest #LFTs ... #Elevation #Transaminitis ... #diagnosis #hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Injury (DILI) ... dose dependent injury ... Chronic - ongoing ↑ LFTs ... #Injury #Idiosyncratic ... gastroenterology #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Injury → liver ... , HSV, VZV • Medications ... #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... involvement, Kidney injury ... duration), Several medications ... #Injury #Diagnosis ... #Algorithm #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... Hepatocellular Level ... #differential #Hepatology ... #transaminitis ... #LFTs #RValue #interpretation
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... Injury Transaminase ... #Patterns #Liver ... #Injury #hepatology ... #LFTs #transaminitis
Liver Function Tests (LFTs) - Normal Values and Interpretation Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
(LFTs) - Normal ... bilirubin (Conjugated/DBili ... hepatocellular injury ... Function #Tests #LFTs ... Interpretation #diagnosis #hepatology
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