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diagnosis differential dermatology management rheumatology secondary generalized pruritus syndrome activation chronic disease fatigue laboratory macrophage mas naildisorders primary rheumatic rheumatoid
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Primary Causes ... Diabetes Mellitus Liver ... • Cholestatic liver ... renal failure/uremia ... #causes
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Iron deficiency anemia ... discoloration) • Liver ... #Secondary #dermatology ... Differential #Diagnosis #Algorithm ... #causes
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Causes of Fatigue ... Renal Failure • Liver ... Neoplastic / Hematologic ... • Anemia • ... • Rheumatoid Arthritis
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
with leukopenia, anemia ... thrombocytopenia • Liver ... ALT ↑ bilirubin level ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Diabetes Mellitus Liver ... • Cholestatic liver ... renal failure/uremia ... Pruritus #secondary #systemic ... #causes
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... affected joint • Systemic ... the presence of anemia ... profile, including liver ... function tests (LFTs
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
the lymphatic system ... Extrapulmonary: ankle arthritis ... heart (2-5%), liver ... (pain/abnormal LFT ... 5-10%, nervous system
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... vasculitis: 10%-16% Liver ... Nephrogenic DI Hematologic ... Arthralgia and Arthritis ... Adenocarcinoma Treatment
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