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Back to the "10 Need to Know" series - Drug Therapeutic Target Levels. 

For lithium, target
vary depending on treatment ... mortality at a higher level ... Therapeutic #Ranges #Toxicology ... #Pharmacology #
Clozapine Toxicology
Clozapine is an atypical antipsychotic most often reserved for use in patients who have treatment-resistant
Clozapine Toxicology ... patients who have treatment-resistant ... metabolized in the liver ... #Clozapine #Toxicology ... Toxicity #Diagnosis #Pharmacology
Neurological Side Effects of Antipsychotic Drugs
Acute dystonia - Spasm of muscles of tongue, face, neck, back
variable tremor, mask ... Extreme rigidity, fever ... months or years of treatment ... months or years of treatment ... #SideEffects #pharmacology
Gout - Diagnosis and Management Summary

3 Conditions for Gout to Manifest:
1. Hyperuricemia
2. Monosodium urate deposition in
not possible • Ultrasound ... Dual-energy CT → MSU ... cortical bone Treatment ... • Acute gout treatment ... • Serum urate level
Overview of antifungal agents benefits, weaknesses, and adverse effects in the treatment of Coccidioidomycosis.
Fluconazole - Low
effects in the treatment ... hypokalemia, phlebitis, fever ... Coccidioidomycosis #coccidioides ... valleyfever #management #treatment ... comparison #table #pharmacology
Methotrexate Toxicology 

Intravenous leucovorin (folinic acid) treatment serves as a cofactor necessary for synthesis of thymidylate
Methotrexate Toxicology ... (folinic acid) treatment ... the serum MTX level ... Leucovorin #Antidote #Toxicology ... Toxicity #Management #Pharmacology
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
vasculitis: 10%-16% Liver ... phenomenon (16%) MSK ... Adenocarcinoma Treatment ... lubricants • Pharmacologic
Antifungal agents benefits, weaknesses, and adverse effects in the treatment of Coccidioidomycosis
Fluconazole
 - Benefits: Low cost/tolerable
effects in the treatment ... hypokalemia, phlebitis, fever ... Coccidioidomycosis #pharmacology ... #management #treatment ... #coccidioides