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leukemia chronic lymphocytic workup aplastic classification cvid gap hemeonc hodgkins hypogammaglobulinemia immunodeficiency immunology lymphoma mds monoclonal myelodysplasia myelodysplastic paraproteinemias polycythemia
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
: • Most common ... Hepatomegaly • Skin ... • Neutropenia, anemia ... #workup #oncology ... #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Leukemia (CLL) ... chemotherapy for low-risk disease ... #Leukemia #oncology ... #hematology #hemeonc ... #diagnosis #management
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... - infiltrates (anemia ... -> Invade Skin: ... #Leukemia #Hematology ... #Oncology #Diagnosis
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
gammopathy, and skin ... gastric tumors • Hematology ... anemia • Other ... Comment on type ... #diagnosis #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Granulomatous lymphocytic ... autoimmune hemolytic anemia ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Headaches • Pale skin ... and petechiae Causes ... antithymocyte globulin ... #oncology #hematology ... #diagnosis #management
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
(NSHL) - (most common ... Immunohistochemical studies (to differentiate ... number of sites of disease ... classification #hematology ... #oncology #management
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Lymphoma (HCV) • CLL ... (-) hemolytic anemia ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Diagnosis Algorithm ... Better call hematology ... workup, think about common ... #Diagnosis #Algorithm ... #workup #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
just beneath the skin ... Most common cytopenia ... Myeloproliferative Disease ... blood count with differential ... #hematology #oncology
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