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differential leukemia chronic hemolytic lymphocytic management monoclonal workup agglutinin classification cold gap globulin hemeonc hodgkins lymphoma mds mgus myelodysplasia myelodysplastic
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Leukemia (CLL) ... leukemia in adults • Disorder ... chemotherapy for low-risk disease ... #Leukemia #oncology ... #hematology #hemeonc
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Hepatomegaly • Skin ... cells can indicate disease ... • Neutropenia, anemia ... #workup #oncology ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... - infiltrates (anemia ... -> Invade Skin: ... #Leukemia #Hematology ... #Oncology #Diagnosis
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
• Symptoms of anemia ... anemia • Cold ... malignancies -> CLL ... IgM monoclonal gammopathy ... #hematology #diagnosis
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Algorithm • Sickle ... Consider sickle cell ... Consider RBC membrane disorder ... #hematology #testing
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
Monoclonal Gammopathy ... No evidence of anemia ... hyperviscosity, lymphadenopathy ... #Significance #hematology ... #diagnosis #oncology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Lymphoma (HCV) • CLL ... (-) hemolytic anemia ... Paraproteinemias #Hematology ... #Differential #Diagnosis ... #Oncology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... Presentation: • Lymphadenopathy ... number of sites of disease ... classification #hematology ... #oncology #management
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
, and skin changes ... gastric tumors • Hematology ... anemia • Other ... #differential #diagnosis ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... just beneath the skin ... Myeloproliferative Disease ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
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