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diagnosis oncology leukemia management chronic common cvid dermatologic gap globulin granulomatosis hodgkins hypogammaglobulinemia immunodeficiency immunology monoclonal paraproteinemias protein proteingap rash
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Cancer affecting lymphocytes ... • Lymphocytes ... #Chronic #Lymphocytic ... workup #oncology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Leukemia): • Lymphocytes ... (Chronic Lymphocytic ... Leukemia): • Lymphocytes ... and/or Small Lymphocytic ... #Leukemia #Hematology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
(GPA) Skin involvement ... GPA causes disease ... Rarely dominate the clinical ... #GPA #dermatology ... rash #diagnosis #rheumatology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
- Clinical Presentation ... HL (MCHL) - Lymphocyte ... HL (LRHL) - Lymphocyte ... LDHL) - Nodular lymphocyte ... #hematology #oncology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to 8 years Clinical ... Granulomatous lymphocytic ... autoimmune hemolytic anemia ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
(HCV) • CLL & ... Alpha & Mu) Skin ... (-) hemolytic anemia ... Paraproteinemias #Hematology ... #Monoclonal #Differential
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
gammopathy, and skin ... gastric tumors • Hematology ... anemia • Other ... #ProteinGap #differential ... #diagnosis #hematology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
elevated protein, lymphocytic ... (PR3-ANCA)): Microscopic ... MPO > PR3 60/ GPA ... tract, and often causes ... #Diagnosis #Rheumatology
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