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diagnosis hepatology differential algorithm acute cirrhosis injury liver management aih biliary cardiology cholangitis common cvid elevated hematology hepatomegaly hypogammaglobulinemia immunodeficiency
Causes of Severe Acute Liver Injury - Ichemic hepatitis - Acute biliary obstruction - Drug-Induced liver
Causes of Severe ... - Autoimmune ... hepatitis - Wilson ... disease - Hemochromatosis ... Severe #Acute #Causes
Clinical Diagnosis of Autoimmune Hepatitis - Onset of jaundice within prior 8 weeks - Ongoing consumption
Clinical Diagnosis of Autoimmune ... Hepatitis - Onset ... of jaundice within ... (Wilson disease ... SMA >1:80 #Autoimmune
Common Etiologies of Cirrhosis Inflammation - Hepatitis B (15 percent) - Hepatitis C (47 percent) - Schistosomiasis
Inflammation - Hepatitis ... 15 percent) - Hepatitis ... Schistosomiasis - Autoimmune ... - Wilson disease ... Hepatology #Cirrhosis #Causes
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 Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
Hemochromatosis • Wilson's ... Disease • Amyloidosis ... • Autoimmune ... Hepatitis • Drug ... Diagnosis #Algorithm #Causes
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
• Ischemia • Autoimmune ... • Wilson's ... • Cholestatic disease ... • Alcoholic hepatitis ... Diagnosis #Algorithm #Causes
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... Hemochromatosis, Wilson's ... Disease, Alpha- ... Other: NAFLD, Autoimmune ... Differential #Diagnosis #Causes
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
• Metabolic: Wilson ... Disease • Vascular ... obstruction syndrome • Autoimmune ... hepatitis • Iatrogenic ... Differential #Diagnosis #causes
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Algorithm Vascular Causes ... Metabolic/Hereditary: Wilson ... • Autoimmune: ... Autoimmune hepatitis ... Chronic viral hepatitis
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
and hepatitis ... Granulomatous lymphocytic ... : Pneumonia • Autoimmune ... thrombocytopenia and autoimmune ... DDX - Other causes
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Pathophysiology: • T lymphocyte ... intralobular bile ducts causes ... hyperpigmentation • Jaundice ... but elevated as disease ... Diagnosis: • Viral hepatitis
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