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diagnosis hematology differential oncology dermatology generalized pruritus secondary systemic chronic classification cll gap globulin hepatomegaly hodgkins lymphoma management mds myelodysplasia
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
cells can indicate disease ... • Richter’s Syndrome ... • Sezary syndrome ... #workup #oncology ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... -> AML: Blast crises ... develop leukostasis syndrome ... • Tumor lysis syndrome ... Leukemia): • Lymphocytes
Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
Differential Diagnosis Algorithm ... • Lymphoma • Leukemia ... Hemochromatosis • Wilson's Disease ... • Budd-Chiari Syndrome ... #Causes #Hepatology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Systemic and Primary Causes ... • Lymphoma • Leukemia ... Myelodisplastic syndrome ... Psychiatric Disease ... #causes
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Cholestatic liver disease ... • Lymphoma • Leukemia ... Myelodisplastic syndrome ... Psychiatric Disease ... #causes
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia ... Myeloproliferative Disease ... Workup: • Complete
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
HL (MCHL) - Lymphocyte ... Hodgkin Lymphoma Workup ... number of sites of disease ... through Ann Arbor criteria ... classification #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... • Plasma cell leukemia ... • Heavy chain disease ... changes (POEMS syndrome ... : Lymphoma, Leukemia
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