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Medications associated with drug-induced lupus

List of Definite and Possible Associated Drugs

#Diagnosis #Pharmacology #Medications #DrugInduced #Lupus #List
Medications associated ... lupus List of ... Definite and Possible ... #Diagnosis #Pharmacology ... #Differential #
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
Mechanisms of Drug-Induced ... • Exogenous (KCL ... #hyperkalemia #differential ... pathophysiology #pharmacology ... #potassium #medications
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Auto-Antibodies: - ANA ... ) 30-45% Differential ... Diagnosis and Lupus ... Mimickers: Drug-induced ... #rheumatology
Hydroxychloroquine Serum Measurement in SLE
 • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
and probably < ... Best indications ... Measurement #SLE #rheumatology ... #pharmacology # ... levels #lupus #management
Serotonin Syndrome Drug Precipitants and Pharmacology
↑ Serotonin Formation: Tryptophan, Oxitriptan
↑ Serotonin Release: Amphetamines, Cocaine, Mirtazapine
↑ Serotonin
Precipitants and ... Pharmacology ↑ ... Lithium ↓ Serotonin Metabolism ... #medications #causes ... #differential #
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
erythematosus (ACLE ... permanent alopecia Differential ... extremities Drug ... La, anti-Jo-1, SCL ... /or medications
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
) • Systemic lupus ... Anti-histone (in drug-induced ... scleroderma) - Anti-Scl ... Jcortesizaguirr #ANA ... antibodies #diagnosis #rheumatology
Drug Induced Systemic Lupus Erythematosus
> 100 drugs have been associated with drug-induced SLE
High risk (>5%):
 •
Lupus Erythematosus ... Erythematosus #medications ... #drugs #pharmacology ... #risk #differential ... #diagnosis #rheumatology
Schematic representation of the major sources of ammonia production and its excretory pathway (GI = gastrointestinal,
decreased metabolism ... ileal conduit - Medications ... Multiple myeloma, CML ... , AML - Large ... Hyperammonemia #Differential
Causes of Acute Pericarditis:

Infectious;

Viral: 
Adenovirus 
Coxsackie virus A and B 
Echovirus 
Epstein-Barr virus 
Hepatitis 
Human immunodeficiency
- related Medication ... induced (select drugs ... Procainamide Metabolic ... syndrome Systemic lupus ... #Pericarditis #Differential