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diagnosis fungal aspergillus betadglucan galactomannan management biomarkers falsepositives hematology hiv hodgkins invasive laboratory lung lymphoma mycobacteria mycoses nonhodgkins nontuberculous ntm
Invasive Aspergillus (IA) - Diagnosis and Management Aspergillus is ubiquitous in nature. Most invasive infections are caused
eg. allogeneic HSCT ... , Advanced HIV/AIDS ... , CGD) Clinical ... presentations: • Pulmonary ... treatment #fungal #infectiousdiseases
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
Non-Hodgkin's Lymphoma - Comparison ... e.g., HIV), EBV infection ... underarms, or chest ... Etiology: - Infections ... Malignancies (eg CML
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
has five major clinical ... aches, joint pain, chest ... fungal stain of clinical ... yeast • At risk: AIDS ... ) #Mycoses #InfectiousDiseases
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
invasive fungal infection ... cut-offs defined in clinical ... /Spec ~80% for IA ... BAL GM does not differentiate ... Galactomannan #diagnosis #comparison
Nontuberculous Mycobacteria (NTM) Infections Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
Disease: Clinical ... • Dyspnea, • Chest ... Lung Disease: • Clinical ... #differential # ... diagnosis #infectiousdiseases
Lung Infections in HIV - Differential Diagnosis Framework Disease by CD4 Count: Any CD4 Count: • Mycobacterium tuberculosis,
Lung Infections ... in HIV - Differential ... #HIV #AIDS #pulmonary ... #differential # ... diagnosis #infectiousdiseases
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
• Neg (<60 pg/mL ... surfaces, Albumin, Infections ... 81% for dx of IA ... in BAL does not differentiate ... 100d following HCT
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