7 results
Diabetes Combination Tablets - Estimated A1c Lowering 
Metformin + DPP4 
• Janumet (metformin + sitagliptin) 
•
Metformin + SGLT2 ... dapagliflozin) Dpp4 + SGLT2 ... Combination #Tablets #Oral ... #DM2 #Pharmacology ... #Pills #Endocrinology
SGLT2 Inhibitors - Pharmacology Summary
Mechanisms of Action: Inhibits SGLT2 (sodium/glucose cotransporter 2) in the proximal tubule,
SGLT2 Inhibitors ... - Pharmacology ... Contraindications: eGFR < 30 mL ... #Inhibitors #Pharmacology ... DM2 #diabetes #endocrinology
SGLT2 Inhibitors 
SGLT2 inhibitors are the newest class of anti-diabetic medications, with the first one (Canagliflozin)
SGLT2 Inhibitors ... SGLT2 inhibitors ... These work by inhibiting ... #Inhibitors #Pharmacology ... DM2 #Diabetes #Endocrinology
Metformin Pharmacology Summary
Mechanisms of Action:
 • Suppresses gluconeogenesis by the liver
 • Increases insulin-mediated glucose utilization
Metformin Pharmacology ... Most effective oral ... initiate if eGFR < 45 mL ... #Metformin #Pharmacology ... DM2 #diabetes #endocrinology
Rybelsus (oral semaglutide) - First Oral GLP-1 Agonist
Dosing:
3 mg daily x 30 days, then 7 mg
) - First Oral GLP ... Otherwise, it works ... when compared to SGLT2 ... semaglutide #Diabetes #Pharmacology ... #Endocrinology
GLP-1 Agonists

Adlyxin (Lixisenatide) Daily
Bydureon (Exenatide ER) Weekly 
Ozempic (Semaglutide) Weekly 
Trulicity (Dulaglutide) Weekly 
Victoza (Liraglutide) Daily
They work primarily ... upset (since it works ... There is an ORAL ... GLP1 #Agonists #Pharmacology ... Diabetes #DM2 #Endocrinology
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook 

Clinical Presentation: 
 • Classic Acromegaly: frontal
Differential Diagnosis ... Diagnosis and Workup ... IGF-1 equivocal: Oral ... levels to <1ng/mL ... Diagnosis #Management #Endocrinology