80 results
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
- Differential Diagnosis ... pylori test (GI symptoms ... test, ANA (e.g., SLE ... (CVID, WAS), (neurologic ... changes), high MCV
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Constitutional symptoms ... NPSLE rare, Malar rash ... constitutional symptoms ... Discontinuation of causal ... #diagnosis #management
Erythroderma - Diagnostic Algorithm. Pathophysiology: 1) Extensive cutaneous capillary dilation, results in widespread exfoliation of the
Erythroderma - Diagnostic ... Pathophysiology: ... Causes: 1) Exfoliative ... Skin-homing T-cells #Diagnosis ... #Dermatology #Rash
Childhood Immunization Schedule: Why we immunize
 • Diphtheria Toxin -> URT inflammation causes pseudomembrane with hardened
& hemorrhagic rash ... ; symptoms of shock ... CNS and hematologic ... Vesicular & pruritic rash ... peds #pediatrics #pathophysiology
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... hair follicles -> causes ... Manifestations #pathophysiology ... #diagnosis #signs ... #symptoms #complications
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Erythematosus (SLE ... Myopathy (Also caused ... Complications #pathophysiology ... #signs #symptoms ... #diagnosis
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
less systemic symptoms ... can present with rash ... including heliotrope rash ... Can also see mechanics ... #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
) - Diagnosis and ... Manifestations: Malar rash ... Positive in 60-80% of cases ... Erythematosus #Diagnosis ... Management #Summary #rheumatology
Anaplasma Infection - Anaplasma phagocytophilum
Pathophysiology: 
 • Obligate, intracellular bacteria
 • Transmitted via blacklegged tick —
phagocytophilum Pathophysiology ... morulae Signs and symptoms ... shaking chills • Rash ... ), cough (30% cases ... Anaplasma #Infection #diagnosis
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
Causes of Anemia ... Corpuscular Volume (MCV ... - Differential Diagnosis ... RA, SLE, PRV, Chronic ... #Hematology